Article abstract Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in affluent societies. In addition to increasing the risk of liver-related morbidity and mortality, hepatic steatosis contributes to the development of cardiometabolic risk. Since NAFLD is a cofactor in other diseases, including hepatitis C, alcohol-associated liver disease, and hemochromatosis, it is now apparent that lifestyle intervention should be incorporated in the routine assessment and care of most patients with liver disease. This review will highlight published evidence on the efficacy of lifestyle interventions in patients with liver disease and conclude with a discussion on the practicability of lifestyle modification strategies in clinical practice.