Low-dose aspirin is associated with a reduction of cardiovascular events and generally recommended in high-risk patients. Its benefit increases with the baseline risk of cardiovascular events. Low-dose aspirin has been shown to be safe when combined with antihypertensive therapy, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Growing evidence shows that not only aspirin’s antiplatelet effect, but also its antioxidant and cytoprotective actions, may be beneficial in patients with hypertension. The latter effects may prevent endothelial dysfunction, restore vasodilator reserve, and subsequently lead to blood pressure lowering effects. These effects seem to be synchronized with circadian rhythms, which are optimal when aspirin is taken at bedtime.Whether low-dose aspirin may have specific antihypertensive effects alone or in combination with antihypertensive therapy is one major question requiring specifically designed trials.