Hot Topics in Hypertension - Editor-in-chief: Massimo Volpe
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HOT TOPICS IN HYPERTENSION: Issue 4, 2008
Role of the renin-angiotensin system in hypertension
Role of the renin-angiotensin system in hypertension
Role of the renin-angiotensin system in hypertension
Kai Kappert, Thomas Unger
Correspondence to:
Thomas Unger - MD, PhD
Professor
Center for Cardiovascular Research
Institute of Pharmacology
Freie Universität Berlin und Humboldt Universität zu Berlin
Charité – Universitätsmedizin Berlin
Berlin, Germany
E-mail: Thomas.Unger@charite.de
Thomas Unger - MD, PhD
Professor
Center for Cardiovascular Research
Institute of Pharmacology
Freie Universität Berlin und Humboldt Universität zu Berlin
Charité – Universitätsmedizin Berlin
Berlin, Germany
E-mail: Thomas.Unger@charite.de
Summary
- THE RENIN-ANGIOTENSIN SYSTEM: HISTORY AND GENERAL ASPECTS
- Biochemistry of the renin-angiotensin system
- Angiotensinogen
- Renin
- Angiotensin-converting enzyme
- Angiotensin receptors
- Renin receptor
- Aldosterone receptor
- HYPERTENSION: GENERAL ASPECTS
- RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND HYPERTENSION
- Renin-induced effects
- Angiotensin-I-induced effects
- Angiotensin-II-induced effects
- Vasoconstriction and blood pressure control
- Salt and blood volume homeostasis
- Cellular responses
- Effects of angiotensin II on different tissues and organs
- Heart
- Vessel wall
- Kidney
- Brain
- Differential effects of angiotensin II receptors and their pathophysiological impact
- Angiotensin-(1-7)
- Angiotensin-III/IV-induced effects
- Aldosterone-induced effects
- OVERVIEW OF DRUGS TARGETING THE RENIN-ANGIOTENSIN SYSTEM
- General pharmacological aspects
- Adverse effects and contraindications of drugs targeting the renin-angiotensin system
- Angiotensin-converting enzyme inhibitors
- AT1 receptor blockers
- Aldosterone receptor antagonists
- Renin inhibition
- ANGIOTENSIN-CONVERTING ENZYME INHIBITORS AND HYPERTENSION
- Clinical trials
- Captopril Prevention Project trial
- Second Australian National Blood Pressure study
- Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
- Conclusion
- AT1 RECEPTOR BLOCKERS AND HYPERTENSION
- Clinical trials
- Losartan Intervention for Endpoint Reduction in Hypertension trial
- Valsartan Antihypertensive Long-Term Use Evaluation trial
- Study on Cognition and Prognosis in the Elderly
- Ongoing clinical trials
- Conclusion
- RENIN INHIBITION AND HYPERTENSION
- Clinical trials
- Conclusion
- ALDOSTERONE RECEPTOR ANTAGONISTS AND HYPERTENSION
- Clinical trials
- Conclusion
- CONCLUDING REMARKS
- REFERENCES
